ProteinQuest · a mode

TwentyFrame

Proteins are built from twenty kinds of building block, called amino acids. Twenty fits on two ten-frames. Here they are, sorted by character the same way you sorted them in ProteinQuest.

• Oily (hydrophobic): 8 kinds (A V L I P F M W)
• Watery (polar): 6 kinds (S T N Q Y C)
• Plus charge: 3 kinds (K R H)
• Minus charge: 2 kinds (D E)
• Glycine (special): 1 kind (G)

Fifty real proteins, twenty blocks at a time

A protein uses the twenty kinds in different amounts. Each card shows about how many of every 20 building blocks in that protein are of each character, counted from its real sequence.

• Insulin
  110 building blocks

• Hemoglobin (alpha)
  142 building blocks

• Hemoglobin (beta)
  147 building blocks

• Green Fluorescent Protein
  238 building blocks

• Alpha-amylase
  511 building blocks

• Antibody (IgG)
  399 building blocks

• Myoglobin
  154 building blocks

• Collagen
  1464 building blocks

• Keratin
  644 building blocks

• Actin
  377 building blocks

• Myosin
  1939 building blocks

• Trypsin
  247 building blocks

• Pepsin
  388 building blocks

• Lactase
  1927 building blocks

• Catalase
  527 building blocks

• Lysozyme
  148 building blocks

• Serum albumin
  609 building blocks

• Ferritin
  183 building blocks

• Casein
  214 building blocks

• Ovalbumin
  386 building blocks

• Cytochrome c
  105 building blocks

• ATP synthase
  529 building blocks

• Tubulin
  451 building blocks

• p53
  393 building blocks

• DNA polymerase
  1462 building blocks

• RNA polymerase II
  1970 building blocks

• Histone H3
  136 building blocks

• Ribosomal protein S6
  249 building blocks

• CRISPR Cas9
  1368 building blocks

• SARS-CoV-2 spike
  1273 building blocks

• ACE2
  805 building blocks

• Rhodopsin
  348 building blocks

• Aquaporin-1
  269 building blocks

• Dopamine D2 receptor
  443 building blocks

• Acetylcholinesterase
  614 building blocks

• Hexokinase
  917 building blocks

• GLUT4 (glucose transporter)
  509 building blocks

• Sodium-potassium pump
  1023 building blocks

• CFTR
  1480 building blocks

• Tyrosinase
  529 building blocks

• Lactoferrin
  710 building blocks

• Beta-lactoglobulin
  178 building blocks

• Silk fibroin
  5263 building blocks

• Antifreeze protein (type I)
  82 building blocks

• Firefly luciferase
  550 building blocks

• Alpha-crystallin A
  173 building blocks

• Hemagglutinin (H1N1 flu)
  565 building blocks

• RuBisCO
  475 building blocks

• Aldolase A
  364 building blocks

• Growth hormone
  217 building blocks

Counted from each protein's full sequence in UniProt, then rounded to twenty, so a card can be off by one from the exact share. Which blocks a protein has is only half the story: where they sit in the folded shape matters just as much.