Proteins · one protein

RNA polymerase II

UniProt P24928 · 1970 residues

AlphaFold's confidence, residue by residue: 963 very high (90 and above) · 449 confident (70 to 90) · 65 low (50 to 70) · 493 very low (below 50).

Ask this protein

• What does it look like? 1970 residues: 49% very high confidence, 25% very low.
• Where could a drug bind?
• Can I print it and fill it in by hand?

The next questions its numbers invite

• Is that floppy bit broken or working? 493 of its 1970 residues are below pLDDT 50.
• Where should it be drawn sketchy? 493 of its 1970 residues are below pLDDT 50.
• Could it be more than one piece, and how sure are they of each other? It is 1970 residues long; long chains are often built from domains.
• What does a single-chain model leave out? Every AlphaFold DB entry is one chain on its own: no partners, metals or cofactors.

These follow-ups come from a short hand-written table that reads only the numbers above: many residues below 50 invites the disorder games; most at 90 or above invites the one about movement. They are questions to try, not findings about this protein.

AlphaFold DB model v6 for UniProt P24928, from Fold Commons' snapshot of 2026-10-04. A prediction, not an experiment.