PocketScout · a mode
Pocket peek
The active site of PTP1B is a pocket at the heart of the folded part. Cys215 sits at the bottom of it. You have 4 looks to find the stretch of chain that carries Cys215. Each look turns one stretch over to a clue. Use the clues: guessing alone finds it about 4 times in 14.
Before you call it: guessing alone would be right about 4 times in 14.
Looks left: 4
Loading the game… If it does not start, the clue key below still explains it.
The clues
- warm: this stretch reaches within 6 Å of Cys215.
- cool: within 10 Å, but not touching.
- cold: more than 10 Å away.
- floppy: the model cannot say where this part sits, so distance here means nothing.
Every clue is worked out from AlphaFold's model of PTP1B (UniProt P18031, model v6) when this page is built: the closest atom of each stretch to the sulfur of Cys215, and the model's own confidence (pLDDT) for the stretch. A stretch whose confidence is below 70 is called floppy, because the model does not place it, so a distance measured to it would mean nothing. Nothing is stored except what you choose to keep, on this device only.