Fold Commons

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Spell the Chain

A protein is a chain of amino acids, written one letter each. Spell a real one, haemoglobin beta (UniProt P68871, 147 letters), one letter at a time. Every letter you type that differs from the real chain is a real substitution: it is named, and its place is marked on AlphaFold's model.

the Sketcher's drawing Prediction Computed by a model, with how sure it is. Not an experiment.

The shape is AlphaFold's prediction for the unchanged chain. Your change is marked on it in magenta, which is not one of AlphaFold's confidence colours. The model is not re-predicted with your change.

The chain to copy

1MVHLTPEEKS11AVTALWGKVN21VDEVGGEALG31RLLVVYPWTQ41RFFESFGDLS51TPDAVMGNPK61VKAHGKKVLG71AFSDGLAHLD81NLKGTFATLS91ELHCDKLHVD101PENFRLLGNV111LVCVLAHHFG121KEFTPPVQAA131YQKVVAGVAN141ALAHKYH


Loading the model…

    Colours on the model: AlphaFold's confidence. very high confident low very low. Your change: magenta.

    The twenty letters

    A alanineR arginineN asparagineD aspartateC cysteineQ glutamineE glutamateG glycineH histidineI isoleucineL leucineK lysineM methionineF phenylalanineP prolineS serineT threonineW tryptophanY tyrosineV valine

    How the numbers count

    Residue numbers here are the database's: they count the first methionine (M) as 1, the way UniProt and the AlphaFold Database number this chain. The finished protein has that first M cut off, so many papers number every residue one lower: the sickle-cell change at residue 7 here is the "E6V" or "Glu6Val" of the textbooks.

    Sequence: UniProt P68871 (vendored 2026-10-04). Model and confidence: AlphaFold DB v6 (CC BY 4.0). What you type stays in this tab; nothing is kept or sent.