Proteins · one protein

Keratin

UniProt P04264 · 644 residues

AlphaFold's confidence, residue by residue: 177 very high (90 and above) · 112 confident (70 to 90) · 39 low (50 to 70) · 316 very low (below 50).

Ask this protein

• What does it look like? 644 residues: 27% very high confidence, 49% very low.
• Where could a drug bind?
• Can I print it and fill it in by hand?
• Can you bet its confidence bar?

The next questions its numbers invite

• Is that floppy bit broken or working? 316 of its 644 residues are below pLDDT 50.
• Where should it be drawn sketchy? 316 of its 644 residues are below pLDDT 50.
• Could it be more than one piece, and how sure are they of each other? It is 644 residues long; long chains are often built from domains.
• What does a single-chain model leave out? Every AlphaFold DB entry is one chain on its own: no partners, metals or cofactors.

These follow-ups come from a short hand-written table that reads only the numbers above: many residues below 50 invites the disorder games; most at 90 or above invites the one about movement. They are questions to try, not findings about this protein.

AlphaFold DB model v6 for UniProt P04264, from Fold Commons' snapshot of 2026-10-04. A prediction, not an experiment.