Proteins · one protein

p53

UniProt P04637 · 393 residues

AlphaFold's confidence, residue by residue: 207 very high (90 and above) · 28 confident (70 to 90) · 41 low (50 to 70) · 117 very low (below 50).

Ask this protein

• What does it look like? 393 residues: 53% very high confidence, 30% very low.
• Where could a drug bind?
• Can I print it and fill it in by hand?
• Do two predictors agree on it?
• Can you bet its confidence bar?

The next questions its numbers invite

• Is that floppy bit broken or working? 117 of its 393 residues are below pLDDT 50.
• Where should it be drawn sketchy? 117 of its 393 residues are below pLDDT 50.
• Could it be more than one piece, and how sure are they of each other? It is 393 residues long; long chains are often built from domains.
• What does a single-chain model leave out? Every AlphaFold DB entry is one chain on its own: no partners, metals or cofactors.

These follow-ups come from a short hand-written table that reads only the numbers above: many residues below 50 invites the disorder games; most at 90 or above invites the one about movement. They are questions to try, not findings about this protein.

AlphaFold DB model v6 for UniProt P04637, from Fold Commons' snapshot of 2026-10-04. A prediction, not an experiment.